Research Awards and Chairs

2021

Hackett, Tillie-Louise
Canada Research Chair – Tier 1
Asthma and Chronic Obstructive Pulmonary Disease Pathobiology and Therapeutics
December 1, 2021 – November 30, 2028

In Canada, over 5.8 million people have asthma and chronic obstructive pulmonary disease (COPD) – diseases for which there is no cure – that make it challenging every day to breathe. Dr. Tillie Hackett’s research uses ultra-resolution imaging to identify lung disease at its earliest stages that cannot be detected using current clinical tests, to define the cellular and molecular alterations responsible for the disease pathobiology. This research will enable a better understanding of how these lung diseases develop, providing new approaches for prediction and diagnosis, resulting in new treatments to improve the lives of asthma and COPD patients.


2020

Gorges, Matthias
Michael Smith Foundation for Health Research – Scholar Award
Optimizing Post-procedural Pain Trajectories Through Patient-oriented Research and Artificial Intelligence
July 1, 2020 – June 30, 2025

Our goal is to use smartphones and artificial intelligence to improve pain management for children having surgery. This is needed because many children still have a lot of pain even a year after surgery. The pain affects their daily life, and might cause them to return to hospital. A child’s pain is affected by many things, like their biological sex, anxiety, coping skills, pain level, and type of surgery. Importantly, some of these can be altered.
We will design a tool to share pain risk data with families and doctors and test these tools in children coming to hospital for spine, tonsil or dental surgery. We hope that using these tools (pain prediction models) will improve the child’s individual care. Identifying children at high pain risk will allow us to intervene before their surgery. This will lead to quicker recovery, less time in hospital, and less chance of addiction to painkillers (opioids).


2018

Griesdale, Donald
Michael Smith Foundation for Health Research – Health Professional Investigator Award
Cerebral Oximetry to assess Cerebral autoregulation in Hypoxemic Ischemic Brain Injury (COnCEpT – HIBI)
July 1, 2018 – June 30, 2023

There are 40,000 patients who suffer a cardiac arrest in Canada each year. When the heart stops beating from a cardiac arrest, blood flow to the brain stops which can lead to large strokes, called ischemic brain injury. Only a small percentage of people who develop ischemic brain injury survive with normal brain function.
The overall goal of this research is to improve the neurologic outcomes of critically ill patients who have suffered a severe brain injury after cardiac arrest by determining how to personalize blood pressure targets for individual patients to ensure adequate cerebral blood flow (CBF). CBF in the first few millimetres of brain tissue can be measured non-invasively by near-infrared spectroscopy (NIRS), using sensors applied to the forehead. I have previously demonstrated that we can use the NIRS to determine the patient-specific blood pressure, but it is unclear if maintaining this individualized blood pressure leads to better outcomes.
The objective is to determine the association between the amount of time spent at the patients individualized blood pressure threshold, and neurologic outcomes at 6-months. The results of this study will be used to design a large interventional study of individualized blood pressure management and neurologic outcomes.


2014

Hackett, Tillie-Louise
Canadian Institutes of Health Research – New Investigator Award
Molecular determinants of small airway obstruction in chronic obstructive pulmonary disease
February 1, 2015 – January 31, 2021

Chronic obstructive pulmonary disease (COPD) is a major cause of mortality and attributes to increased health care costs in Canada due to its prevalence and a lack of disease-modifying therapies. COPD is characterized by irreversible lung function decline that is caused by destruction of lung elastic tissue and obstruction of the small airways, which allow airflow in and out of the lungs. In COPD, these lesions are produced in response to repetitive inhalational injury inflicted by smoke exposure but the mechanisms are unknown. The goal of this research is to identify the molecular determinants of small airway lesions in COPD and test if they are potential modifiable targets for COPD.


Hackett, Tillie-Louise
Michael Smith Foundation for Health Research – Scholar Award
Molecular determinants of small airway obstruction in chronic obstructive pulmonary disease
February 1, 2015 – January 31, 2021

Dr. Hackett’s research program is focused on understanding the disruption of normal repair processes within the epithelial-mesenchymal trophic unit (EMTU) of the lung and how this propagates inflammation and tissue remodeling in patients with obstructive lung disease.
Dr. Hackett’s laboratory uses an innovative and targeted approach to isolate cells from donor lungs guided by Computed Tomography imaging. This resource, The Human Lung Cell Repository, aims to provide highly characterized cells representative of a variety of lung disease states and healthy individuals for use in clinical bio-assays of disease.
The goal of this research program is to further understand the airway microenvironment to determine therapeutic targets to prevent the initiation and perpetuation of pathological processes which contribute to obstructive airway diseases like asthma and chronic obstructive pulmonary disease.