2018 Visiting Professor Lecture - Dr. Philip Peng

2018 Visiting Professor Lecture – Dr. Philip Peng

October 25, 2018


Time: Wednesday, November 7 2018

Venue: 6:00PM-7:00PM: Rm. 1441, Taylor-Fidler Auditorium, Jim Pattison Pavilion North
Vancouver General Hospital

Title: “Innervation of Hip Joint – Reflect on the Regional Anesthesia Blockade for Hip”

 

Dr. Philip Peng ,MMBS, FRCPC

Professor
Department of Anesthesia and Pain Management
University of Toronto

Objectives:

  1. To update the most recent understanding of the innervation to the hip
  2. To reflect upon the rationale which the regional anesthesia for hip based on in the past.
  3. To describe the new procedure based on the new understanding of hip innervation

Brief CV:

Dr. Philip Peng is a full time professor in the Department of Anesthesia and Pain Management of University of Toronto. He is currently the director for Anesthesia Pain Management Center. He has played an important role in the education of pain medicine and established major teaching courses. Royal College of Physicians and Surgeons of Canada (RCPSC) honored him with Founder designation in Pain Medicine for his role in establishing Pain Medicine subspecialty in Canada. He is also a leader and pioneer in the application of ultrasound for pain medicine. He has edited 7 books and published more than 150 peer-reviewed and publications and book chapters.

Reception: 5:30 PM – 6:00 PM (Light Refreshments will be served)
Taylor Fidler Auditorium (hallway), Jim Pattison Pavilion VGH
(Note: no food or drink allowed inside the auditorium)

Department of Anesthesiology, Pharmacology & Therapeutics Annual Report 2017

September 25, 2018

Thank you for taking a few minutes to go through this report. This year the report highlights a few areas in our department, with the usual detailed information placed as appendices. Please share with colleagues in your department, so they too can celebrate the successes of our colleagues as well as hopefully understand this diverse department a little better.

Download Report

Department of Anesthesiology, Pharmacology & Therapeutics Seminar: Dr. Zheng Xie, M.D., Ph.D.

September 24, 2018


Time: Thursday, October 11, 2018 at 11:00 AM.

Venue: IRC 5 lecture hall.

Title: Anesthetic Mechanisms: From molecules to humans

 

Dr. Zheng , M.D., Ph.D.

Associate Professor

Department of Anesthesia and Critical Care

University of Chicago.

 

RESEARCH INTERESTS:

Tens of millions of patients worldwide, from newborn to elderly, receive anesthesia each year. The mechanisms of Anesthetics remain largely unresolved despite significant progress over the past several decades. Recently, evidence has been uncovered suggesting that anesthetics are neurotoxic to the developing brain in animals and possibly in humans. In 2016, the FDA issued a warning about the potential long-term risks to cognitive functions in children who receive multiple or prolonged anesthesia during their early life (<3 year of age or during the third trimester of pregnancy of their mothers). Anesthetics may also cause significant deterioration in the cognitive functions of elderly patients. It is critically important for us to better understand the underlying mechanisms of anesthetic effects and related toxicities. My main research goal is to deepen our understanding of anesthetic mechanisms at the molecular level, in animal and human studies. We showed, using electrophysiological and molecular techniques, that anesthetics inhibit neurotransmitter release by interacting with neurotransmitter release machinery in neurons and chromaffin/PC-12 cells. Recently we found that drugs which elevate intracellular cAMP and/or block adenosine receptors could facilitate emergence from isoflurane and propofol anesthesia in rats. In a recent human trial, we reported that caffeine facilitates isoflurane anesthesia emergence in healthy volunteers. Our goal is to translate the current basic research findings to future clinical use in humans. Other ongoing studies involve anesthetic effects in autistic animal models and drugs which can reduce anesthetic induced neurotoxicity in the developing brain.

 

Representative publications:

Xie Z, Currie KPM and Fox AP: Etomidate elevates intracellular calcium levels and promotes catecholamine secretion in bovine chromaffin cells. J Physiol. (London) 560.3: 677-690 2004. http://jp.physoc.org/content/560/3/677.full?sid=ef6f9266-c409-49ce-ae35-e3a638e97a56

Xie Z, Herring BE and Fox AP: Excitatory and inhibitory actions of isoflurane in bovine chromaffin cells. J Neurophysiol. 96: 3042-3050 2006. http://jn.physiology.org/cgi/reprint/00571.2006v1

Herring BE, Xie Z, Marks J and Fox AP : Isoflurane inhibits the neurotransmitter release machinery via an interaction with syntaxin 1A. J Neurophysiol. 102: 1265 – 1273, 2009. http://jn.physiology.org/cgi/reprint/102/2/1265.pdf

Herring BE, McMillan K, Fox AP and Xie Z: Etomidate and Propofol Inhibit The Neurotransmitter Release Machinery at Different Sites. J Physiol. (London) 589.5, 1103-1115, 2011. http://jp.physoc.org/content/589/5/1103.full.pdf+html?sid=19d7919e-d643-4b4e-9202-6bb6d51e015b.

Xie Z, McMillan K, Wang, Q and Fox, AP: Interaction of anesthetics with SNARE proteins identified with RNAi. J Neurophysiol. 109:758-767, 2013. http://jn.physiology.org/content/109/3/758.full.pdf+html?sid=9a365e95-6050-496e-8312-cd5d358cfbe1

Wang Q, Fong R, Mason P, Fox AP and Xie Z: Caffeine Accelerates Recovery from General Anesthesia. J Neurophysiol. 111: 1331-1340, 2014 http://jn.physiology.org/content/jn/111/6/1331.full.pdf

 

 

Congratulations to our 2018 Anesthesia Residency Graduates!

July 27, 2018

Research Day 2018 Guest Lecture – Dr Steven Schafer

June 21, 2018

The 2018 Anesthesiology, Pharmacology & Therapeutics Research Day 2018 Guest Lecture is available here

“Clinical Pharmacology – A Journey from Michael Jackson to TensorFlow”

Steven L. Shafer, MD

Professor of Anesthesiology, Perioperative and Pain Medicine, Stanford University
Adjunct Associate Professor of Bioengineering and Therapeutic Sciences, UCSF

 

Dr. Shafer’s professional interests are the clinical pharmacology of intravenous anesthetic drugs, opioids and hypnotics used in anesthetic practice. However, his real passion is not the drugs themselves, but rather the mathematical models that characterize drug behavior. These include conventional pharmacokinetic and pharmacodynamic models, inverse models (used to drive target controlled infusion systems), Bayesian models (used to handle model uncertainty), pharmacokinetic and pharmacodynamic models of drug interaction, models of receptor function that help elucidate mechanisms of drug action, and models that relate drug response to “in silico” pharmacogenetics.

 

 

APT Department Seminar: Pascal Bernatchez

May 22, 2018


Dr. Pascal Bernatchez

Associate Professor
Department of Anesthesiology, Pharmacology & Therapeutics
Faculty of Medicine, University of British Columbia

 

 

 

New pharmacological options for heritable aortopathies and muscle disorders: old dog, new tricks?

Genetic aortopathies and muscular dystrophies are two seemingly unrelated groups of diseases with poor management options. Our laboratory has recently shown that cardiovascular medications that target the LDL-cholesterol synthesis pathways and the vasculature, particularly the endothelium, offer untapped therapeutic potential for patients afflicted by these conditions. Using classic and molecular pharmacology principles, we study how these medications mediate their unexpected effects and whether better treatments can be translated to the clinic.

 

Time: Thursday, June 7, 2018 at 11:00am
Location: Room B151 of School of Population and Public Health (2206 East Mall, UBC)
Hosts: Dr. Pascal Bernatchez pascal.bernatchez@ubc.ca

All are welcome!

 

Research Day 2018 Keynote speaker: Dr Steven Shafer

May 16, 2018


Dr. Steven Shafer

Professor of Anesthesiology, Perioperative and Pain Medicine
Stanford University

 

 

Clinical Pharmacology: From Michael Jackson to Tensor Flow

Dr. Shafer’s professional interests are the clinical pharmacology of intravenous anesthetic drugs, opioids and hypnotics used in anesthetic practice. However, his real passion is not the drugs themselves, but rather the mathematical models that characterize drug behavior. These include conventional pharmacokinetic and pharmacodynamic models, inverse models (used to drive target controlled infusion systems), Bayesian models (used to handle model uncertainty), pharmacokinetic and pharmacodynamic models of drug interaction, models of receptor function that help elucidate mechanisms of drug action, and models that relate drug response to “in silico” pharmacogenetics.

 

Time:  Tuesday, May 22, 2018 at 6:15pm
Location:  Paetzold Auditorium (Jim Pattison Pavilion- Vancouver General Hospital)
Hosts: Dr. Don Griesdale donald.griesdale@ubc.ca Dr. Pascal Bernatchez pascal.bernatchez@ubc.ca

 

Dr. Jean Templeton Hugill Visiting Professor Lecture – Video

May 14, 2018

The Dr. Jean Templeton Hugill Visiting Professor Lecture is available here

“Local anesthetics – old drugs with a bright future”

Philipp Lirk, MD, PhD
Associate Professor of Anaesthesia, Harvard Medical School
Attending Anesthesiologist, Brigham and Women’s Hospital, Boston, MA, USA

 

Dr. Jean Templeton Hugill was one of the first female anesthesiologists in Western Canada in the 1950s. She earned a reputation for taking on difficult cases and became a key figure in developing obstetric anesthesia in BC. After a long career devoted to clinical care, Dr. Hugill was determined to support anesthesia research, which she said she was always interested in but unable to pursue herself. Motivated to facilitate collaborative research between anesthesiologists and pharmacologists, Dr. Hugill left a bequest to the Faculty of Medicine upon her death in 2012, adding to her previous 1991 gift that was matched by the BC Government to establish an endowed Chair in Anesthesia.

Dr. Philipp Lirk obtained his MD from the University of Innsbruck, Austria. After a Postdoctoral Research Fellowship at the Medical College of Wisconsin, he trained in Anesthesia & Critical Care in Innsbruck, and completed an MSc at the University of Cardiff (UK). In 2010, Dr. Lirk was appointed to the Academic Medical Center Amsterdam, where he served as Head of Regional Anesthesia. In 2015, he earned a PhD at the University of Amsterdam with work on the pharmacology of local anesthetics. In 2017, Dr. Lirk moved to Boston to work at Brigham and Women’s Hospital, and currently divides his time between research on local anesthetics and anesthesia care for orthopedics & trauma. He is an Associate Editor of the European Journal of Anaesthesiology; member of the European Society of Anaesthesiology’s Scientific Subcommittee on Regional Anesthesia; and member of the PROSPECT Working group of the European Society of Regional Anesthesia and Pain Therapy.

 

 

Dr Roanne Preston reappointed as Head of Anesthesiology Pharmacology & Therapeutics

April 26, 2018

Announcement:

We would like to congratulate Dr Roanne Preston on being reappointed in her role as the head of Anesthesiology Pharmacology & Therapeutics. Dr Preston has demonstrated strong leadership in fostering excellence and innovation in education, research and health care. We are very pleased that she will continue in her role to June 30th, 2022.

2017/18 Annual Dr. Jean Templeton Hugill Visiting Professor Lecture

April 25, 2018

The UBC Department of Anesthesiology, Pharmacology & Therapeutics

is proud to announce the 2017/18 annual

Dr. Jean Templeton Hugill Visiting Professor Lecture

 “Local anesthetics – old drugs with a bright future”

Philipp Lirk, MD, PhD
Associate Professor of Anaesthesia, Harvard Medical School
Attending Anesthesiologist, Brigham and Women’s Hospital, Boston, MA, USA

 

Wednesday, April 25, 2018 at 6:00 pm

Vancouver General Hospital, Jimmy Pattison Pavilion, Third Floor, Room JPPN 3414

910 West 10th Avenue, Vancouver, BC

A reception with light refreshments will be held prior to the lecture at 5:30 pm (JPPN 3336).

Dr. Jean Templeton Hugill was one of the first female anesthesiologists in Western Canada in the 1950s. She earned a reputation for taking on difficult cases and became a key figure in developing obstetric anesthesia in BC. After a long career devoted to clinical care, Dr. Hugill was determined to support anesthesia research, which she said she was always interested in but unable to pursue herself. Motivated to facilitate collaborative research between anesthesiologists and pharmacologists, Dr. Hugill left a bequest to the Faculty of Medicine upon her death in 2012, adding to her previous 1991 gift that was matched by the BC Government to establish an endowed Chair in Anesthesia.

Dr. Philipp Lirk obtained his MD from the University of Innsbruck, Austria. After a Postdoctoral Research Fellowship at the Medical College of Wisconsin, he trained in Anesthesia & Critical Care in Innsbruck, and completed an MSc at the University of Cardiff (UK). In 2010, Dr. Lirk was appointed to the Academic Medical Center Amsterdam, where he served as Head of Regional Anesthesia. In 2015, he earned a PhD at the University of Amsterdam with work on the pharmacology of local anesthetics. In 2017, Dr. Lirk moved to Boston to work at Brigham and Women’s Hospital, and currently divides his time between research on local anesthetics and anesthesia care for orthopedics & trauma. He is an Associate Editor of the European Journal of Anaesthesiology; member of the European Society of Anaesthesiology’s Scientific Subcommittee on Regional Anesthesia; and member of the PROSPECT Working group of the European Society of Regional Anesthesia and Pain Therapy.

Host: Dr. Stephan Schwarz, UBC Dr. Jean Templeton Hugill Chair in Anesthesia.

This lecture will be broadcasted live to various hospital sites, including the following:
NRGH 2053, RJH CA 011, VGH 1914, UHNBC 5030, RH 1763, LGH 2506, and RCH 017.

How to attend remotely: Note: Use a computer. Mobile devices (smart phones, tablets) are not supported.

1. Web browser:  In Chrome browser, go to http://meet.vc.ubc.ca and enter the 5 digit conference/bridge ID, 30303. For instructions and troubleshooting, see the Web Browser User Guide.  2. Skype for Business: enter 30303@vc.ubc.ca to join the meeting.  Note: Your personal Skype is not compatible with Skype for Business. Refer to the troubleshooting guide.  3. Telephone (Audio-bridge): Dial the toll-free phone number, 1-844-521-0666, followed by the 5 digit ID (30303), followed by #.