Daniel Sastre Martinez

Daniel Sastre Martinez

Daniel Sastre Martinez

Postdoctoral Research Fellow

Faculty Bio

I am a postdoctoral fellow investigating the regulation and pharmacology of the cardiac ion channel KCNQ1 with the aim of deciphering the biological mechanisms underlying cardiac arrhythmia and proposing improved therapeutic strategies. My research bridges molecular biology, neuroscience, and pharmacology, focusing on uncovering mechanisms that drive ion channel function. Combining patch clamp electrophysiology, voltage clamp fluorometry and ion channel simulations in Python, along with expertise in confocal microscopy and biochemistry, I integrate diverse methodologies to address complex biological questions. Throughout my career, I have been recognized with awards for 3 poster presentations, received 3 competitive fellowships, delivered 6 scientific presentations, and contributed to 14 published works.

Social Media / Lab or Research Website

Website (or Lab): 


Research Interests

Cardiomyopathies, Cardiac Arrhythmia, Long and Short QT Syndromes, Atrial Fibrillation

Research Theme(s)

Publication Link(s)

ORCID: 0000-0001-9471-9398

Google Scholar: https://scholar.google.ca/citations?user=DpSqAocAAAAJ&hl=en


Clinical Interests

Cardiac Arrhythmia


Services


Teaching


Stephan K.W. Schwarz

Stephan K.W. Schwarz

Portrait photo of Stephan K.W. Schwarz
Professor
Editor-in-Chief, Canadian Journal of Anesthesia
St. Paul’s Hospital

Faculty Bio

Dr. Stephan Schwarz obtained his primary medical degree as well as a postgraduate medical research doctorate from the University of Göttingen/Germany. In 1995, he relocated to Vancouver/Canada to pursue a PhD in Pharmacology & Therapeutics at The University of British Columbia (UBC), followed by a residency in anesthesia and completion of the Royal College of Physician and Surgeons of Canada Clinician Investigator Program (CIP). 

In 2004, he became member of the anesthesia staff at St. Paul’s Hospital/Providence Health Care, where he subsequently was appointed Anesthesia Research Director, a position he occupied for three terms. Simultaneously, he was appointed as Assistant Professor in the UBC Department of Anesthesiology, Pharmacology & Therapeutics, where he was promoted to Associate Professor with tenure in 2011 and full Professor in 2017.

In 2014, Dr. Schwarz was awarded UBC’s endowed Dr. Jean Templeton Hugill Chairship in Anesthesia. Since then, he has served as Director of the UBC Hugill Anesthesia Research Centre, a collaborative initiative within the UBC Department of Anesthesiology, Pharmacology & Therapeutics under the aegis of the Hugill Chairship. Nationally, Dr. Schwarz has served on the Canadian Anesthesiologists’ Society (CAS) Research Advisory Committee, the CAS Grant Adjudication Subcommittee, and the CAS Ethics Committee. 

A passionate lecturer, Dr. Schwarz has been an invited speaker at many national and international conferences and has won numerous research and teaching awards; in 2017, he was awarded a UBC Killam Teaching Prize, UBC’s most prestigious award in recognition of excellence in education.

Using in vitro and in vivo laboratory techniques as well as clinical studies, Dr. Schwarz’ research explores the neuropharmacology of anesthesia and analgesia and aims to build bridges between bench and bedside. A particular area of focus has been local anesthetic pharmacology. His CV lists over 230 published articles and abstracts. His areas of clinical interest are Adult Anesthesia, Regional Anesthesia, and Perioperative Medicine.

Taking advantage of his multidisciplinary training and activities that include clinical anesthesiology; basic neurosciences and pharmacology; evidence-based medicine; experimental design; and data analysis, Dr. Schwarz is a veteran, internationally recognized editorial peer reviewer. He has been presented with “Top Reviewer” awards from Anesthesiology and the Canadian Journal of Anesthesia and has served as a peer reviewer for The Lancet and the New England Journal of Medicine. In 2014, he was appointed to the Editorial Board of the Canadian Journal of Anesthesia and in 2020 was selected as its new Editor-in-Chief, a position which he has occupied since January 1, 2021.

Social Media / Lab or Research Website

Website (or Lab): 


Research Interests

Using in vitro and in vivo laboratory techniques as well as clinical studies, Dr. Schwarz’ research explores the neuropharmacology of anesthesia and analgesia and aims to build bridges between bench and bedside. A particular area of focus has been local anesthetic pharmacology.

Research Theme(s)

Publication Link(s)


Clinical Interests

General Adult Anesthesia; Regional Anesthesia; Ambulatory Anesthesia; Perioperative Medicine


Services


Teaching


John Kipling Kramer

John Kipling Kramer

Associate Professor
Principal Investigator, International Collaboration on Repair Discoveries (ICORD)

Faculty Bio

Social Media / Lab or Research Website

Website (or Lab): 


Research Interests

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Clinical Interests


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Teaching


Darryl Knight

Darryl Knight

Portrait photo of Darryl Knight
Professor
Associate Dean, Research, Providence Health Care Research Institute
Vice President, Research & Academic Affair, Providence Health Care
St. Paul’s Hospital

Faculty Bio

Dr. Knight obtained his PhD at the University of Western Australia in 1993 and did post doctoral training at the University of British Columbia. From 1997 to 2001 he was a Senior Research Officer in the Asthma & Allergy Research Institute of the University of Western Australia and was Head of the Experimental Biology division of the Institute from 2002-2004. He was also an Adjunct Senior Lecturer in the Department of Medicine at the University of Western Australia.

Dr. Knight’s research program consists of complementary projects centered on understanding how the respiratory system repairs itself after inflammatory insult and why in susceptible asthmatics, inflammation results in ongoing and abnormal remodeling rather than a self-limited healing process. The particular focus of this program is the epithelial cell and fibroblast in modulating the repair process.

Social Media / Lab or Research Website

Website (or Lab): 


Research Interests

The current objectives of Dr. Knight’s research program are centred on investigating the mechanisms of airway epithelial repair following damage induced by a variety of stimuli focusing on 3 key objectives: (1) Characterize the phenotype of epithelial-resident progenitor cells involved in repair in human airways (2) Determine whether bone marrow derived progenitor cells play a role in epithelial repair, and if so, what is the relative contribution of these cells to tissue resident progenitor cells under normal conditions and in the presence of underlying allergic disease (3) Examine whether airway progenitor cells have potential for both epithelial and mesenchymal differentiation.

Dr. Knight is also actively investigating the role of the IL-6/gp130 in the pathogenesis of pulmonary fibrosis. The specific goal of this project is to identify novel molecular mechanisms for the treatment, diagnosis and prognosis of IPF focusing on our insights that cytokines that signal through gp130 may be critical determinants of disease susceptibility and progression. gp 130 is a shared component in the receptor complexes for the IL-6 family of cytokines that also includes IL-11, Leukemia Inhibitory Factor (LIF) and Oncostatin M (OSM) which are important regulators of both the phenotype and proliferation of fibroblasts in health and in response to injury.

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Publication Link(s)


Clinical Interests


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Teaching


Andrew Horne

Andrew Horne

Associate Professor of Teaching
Vice Chair, Education – Anesthesiology, Pharmacology & Therapeutics

Faculty Bio

Faculty Member in the Department since 2011. Holds his BSc (Pharmacology) and PhD (Physiology) from UBC.

Social Media / Lab or Research Website

Website (or Lab): 


Research Interests

Neurosciences and anesthesiology

Research Theme(s)

Publication Link(s)


Clinical Interests


Services

Vice Chair, Education


Teaching

PCTH_V 201 (Course Director)

PCTH_V 404 (Course Director)

PCTH_V 201

PCTH_V 301

PCTH_V 302

PCTH_V 303

PCTH_V 325

PCTH_V 400

PCTH_V 402

PCTH_V 404


Joanne YT Leung

Joanne YT Leung

Instructor

Faculty Bio

Social Media / Lab or Research Website

Website (or Lab):


Research Interests

Research Theme(s)

Publication Link(s)


Clinical Interests


Services


Teaching

MIDW_V 125

PCTH_V 201

PCTH_V 301

PCTH_V 302

PCTH_V 303

PCTH_V 325

PCTH_V 400


David Fedida

David Fedida

Portrait photo of David Fedida
Professor
Principal Investigator, Life Sciences Institute (LSI)

Faculty Bio

David Fedida obtained his B.Sc. and Ph.D. degrees at the University of Leeds in England in cardiac electrophysiology and his medical Degree (BM, B.Ch.) from Oxford University. After a brief period spent in residency training in General Surgery and Cardiovascular Medicine in the UK, he spent postdoctoral periods at Oxford with Denis Noble, Wayne Giles in Calgary, and Arthur Brown at Baylor College of Medicine in Texas where he first identified Kv1.5 as the molecular basis of the delayed rectifier, IKur, in human atrium.

Presently he is a Professor in the Department of Anesthesiology, Pharmacology & Therapeutics with funding from the Heart and Stroke Foundation of BC and Yukon and The Canadian Institutes for Health Research. This funding is to study molecular mechanisms for the gating of voltage-activated potassium channels, trafficking of potassium channels in the heart and for the discovery of small molecule inhibitors of viral ion channels, viroporins, for treatment of viral infections.

David Fedida is also a consultant for Cardiome Pharma Corp in Vancouver where he has been involved in the design and electrophysiological testing of Cardiome’s agents for the treatment of supraventricular arrhythmias – notably Vernakalant, which has been shown to be successful in the conversion of recent onset atrial fibrillation (AF) in Phase II and III trials and has European approval for the IV treatment of AF.

Social Media / Lab or Research Website

Website: http://www.ionsgate.com/

Lab: https://crg.lsi.ubc.ca/primary-members/fedida-lab/


Research Interests

Voltage-activated potassium channels, Trafficking of potassium channels in the heart and for the discovery of small molecule inhibitors of viral ion channels, Viroporins, For treatment of viral infections

Research Theme(s)

Publication Link(s)

PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=david+fedida


Clinical Interests


Services


Teaching


Clinton Wong

Clinton Wong

Clinical Professor
St. Paul’s Hospital

Faculty Bio

Clinton Wong MD FRCPC (Anesthesiology and Pain Medicine), MCFP (Hon.) Consultant Anesthesiologist and Pain Medicine Physician, Division of Acute and Interventional Pain Management Department of Anesthesiology St. Paul’s Hospital (Providence Healthcare) Clinical Professor Department of Anesthesiology, Pharmacology and Therapeutics UBC Faculty of Medicine Vancouver, BC After obtaining an MD from UBC in 1983, and completing a rotating internship at North York General Hospital, plus one year of anesthesia residency at UBC, Clinton Wong worked as a GP/GP Anesthetist in Fort Nelson, BC. He returned to complete the UBC Anesthesiology residency in 1991. Formerly a consultant anesthesiologist at Shaughnessy Hospital and Riverview Hospital, he is currently at St. Paul’s Hospital where he is a member of the Division of Acute and Interventional Pain Management, including past physician lead, Acute Pain Service. He obtained certification by the RCPSC in the Pain Medicine subspecialty in 2016. His current clinical areas of interest are perioperative anesthesiology and chronic pain. He has an interest in postgraduate medical education, with previous roles as SPH site coordinator for anesthesia residents, UBC Anesthesiology Residency program director, and member of RCPSC Specialty Committee in Anesthesiology, including vice-chair. He was a contributor to the RCPSC Anesthesiology National Curriculum, used to guide residency programs in developing training programs, and by RCPSC Examination Board for national exam criteria. He has contributed to the development of Entrustable Professional Activities(EPA’s) for RCPSC Anesthesiology’s version of Competence Based Medical Education, and a similar process for the CFPC’s Family Practice Anesthesia Certificate of Added Competence (“Priority Topics” and “Key Features”). He was a surveyor for RCPSC Accreditation reviews of Canadian PGME residency programs. He was a founding member of the UBC Pain Medicine Residency, and is currently a member of the UBC Anesthesiology Residency Program’s Competence Committee, and the UBC Postgraduate Medical Education’s Oversight Committee for residents in difficulty.

Social Media / Lab or Research Website

Website (or Lab): 


Research Interests

Research Theme(s)

Publication Link(s)

ORCID: 0000-0003-3512-2967


Clinical Interests

Current clinical areas of interest: perioperative anesthesiology and chronic pain. Postgraduate medical education.


Services

Past SPH site coordinator for UBC Anesthesia residents past UBC Anesthesiology Residency Program Director past member of RCPSC Specialty Committee in Anesthesiology including vice chair, during which time this committee developed the framework for CBME/CBD with Entrustable Professional Activities past RCPSC Accreditation surveyor past member of the CFPC’s ad hoc committee to develop Family Practice Anesthesia Certificate of Added Competence (“Priority Topics” and “Key Features”) founding member of the UBC Pain Medicine Residency residency training program committee current member UBC Anesthesiology Residency Program’s Competence Committee current member UBC Postgraduate Medical Education’s Oversight Committee for residents in difficulty.


Teaching

Coordinated and/or gave many lectures for the UBC Anesthesiology Residency Program as SPH site coordinator (9+ years), and UBC Anesthesiology Residency Program Director (8.5 years). Still give annual lectures to final year UBC Anesthesiology residents in the form of R5 Seminar series on the topic of chronic pain.


Simon Whyte

Simon Whyte

Clinical Associate Professor
BC Children’s Hospital

Head, Pediatric Anesthesia, BC Children’s Hospital Head; UBC APT Division of Pediatric Anesthesia

Faculty Bio

Dr. Sadiq Abdulla is an Anesthesiologist at BC Women’s Hospital. He has a clinical fellowship in Obstetric Anesthesia from Mount Sinai Hospital inToronto, Ontario. He has also completed the UBC Sauder Physician Leadership Program and was the inaugural Associate Program Director for theAnesthesia Training Program. His research interests include optimizing uterotonic use, ultrasound use in obstetric anesthesia, and developing anenhanced recovery pathway for cesarean delivery. He is currently a Royal College of Physician and Surgeons of Canada examiner for the Anesthesiology specialty.

Social Media / Lab or Research Website

Website (or Lab): https://bcchr.ca/PART



Clinical Interests

Pediatric anesthesia, including development of perioperative management guidelines for children with long QT syndromes; development of comparative, anonymized, individual feedback as a driver of continuous quality improvement; and establishment & dashboarding of a pediatric difficult intubation
registry. Current & future work focused on improving individualized TIVA regimens by examining pharmacodynamic-pharmacogenomic relationships
with anesthetic drugs used in children.


Services


Teaching


Jennifer M Whittingham

Jennifer M Whittingham

Clinical Associate Professor
Nanaimo Regional General Hospital

Faculty Bio

Graduated from McMaster (MD, 2005; FRCPC 2010). Associate professor NOSM (2010-2019). Site Education Coordinator, Competency Committee Thunder Bay Regional Health sciences Centre/NOSM Anesthesia Program (2011-2019).

Social Media / Lab or Research Website

Website (or Lab): 


Research Interests

Research Theme(s)

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Clinical Interests


Services

Site Director Education – Thunder Bay Regional Hospital/NOSM (2011-2019); Competency Committee NOSM FRCPC and FPA program (2016-2019); Simulation instructor NOSM FPA Bootcamp Course (2013-2018); Interview Committee NOSM FRCPC (2013-2019)


Teaching

Simulation instructor NOSM Bootcamp FPA SIM Program (2013-2018); Undergraduate CBL teaching UBC (yr 1/yr 2)-2018/2019