Rudolf Vrba Memorial Lecture November 6th, 2017

The Department of Anesthesiology, Pharmacology & Therpeutics welcomes you to the 2017/2018 Rudolf Vrba Memorial Lecture.

Time: Monday, November 6th, 2017 at 6:30pm
Location: LSC 1001 (2350 Health Sciences Mall, UBC)
Dr. David Fedida
Dr. Pascal Bernatchez

There will be a reception with food and drinks served at 5:30pm in West Atrium.

All are welcome!

Guest Speaker:

Joseph Schlessinger , PhD
William H. Prusoff Professor and Chairman
Department of Pharmacology
Yale University School of Medicine


Cell Signaling By Receptor Tyrosine Kinases; from basic Principles to Cancer Therapy

We are interested in analyzing the mode of action of growth factor receptors and the
intracellular signaling pathways that activated in response to growth factor
stimulation. Receptor tyrosine kinases and cytoplasmic protein tyrosine kinases play
a critical role in the control of many cellular processes including: cell proliferation,
differentiation, metabolism, as well as cell survival and cell migration. Various
diseases are caused by dysfunctions in protein tyrosine kinases or in components of
signaling pathways that are activated by these enzymes. We have used biochemical
and genetic approaches as well as x-ray crystallography to determine the mechanism
of activation of receptor tyrosine kinases and the mode of action of downstream
signaling proteins.