APT Department Seminar: Pascal Bernatchez
Genetic aortopathies and muscular dystrophies are two seemingly unrelated groups of diseases with poor management options. Our laboratory has recently shown that cardiovascular medications that target the LDL-cholesterol synthesis pathways and the vasculature, particularly the endothelium, offer untapped therapeutic potential for patients afflicted by these conditions. Using classic and molecular pharmacology principles, we study how these medications mediate their unexpected effects and whether better treatments can be translated to the clinic.
Research Day 2018 Keynote speaker: Dr Steven Shafer
Dr. Shafer’s professional interests are the clinical pharmacology of intravenous anesthetic drugs, opioids and hypnotics used in anesthetic practice. However, his real passion is not the drugs themselves, but rather the mathematical models that characterize drug behavior. These include conventional pharmacokinetic and pharmacodynamic models, inverse models (used to drive target controlled infusion systems), Bayesian models (used to handle model uncertainty), pharmacokinetic and pharmacodynamic models of drug interaction, models of receptor function that help elucidate mechanisms of drug action, and models that relate drug response to “in silico” pharmacogenetics.
Dr. Jean Templeton Hugill Visiting Professor Lecture – Video
The Dr. Jean Templeton Hugill Visiting Professor Lecture is available now for download.