The Department of Anesthesiology, Pharmacology & Therpeutics welcomes you to the 2017/2018 Rudolf Vrba Memorial Lecture.
There will be a reception with food and drinks served at 5:30pm in West Atrium.
All are welcome!
Joseph Schlessinger , PhD
William H. Prusoff Professor and Chairman
Department of Pharmacology
Yale University School of Medicine
Cell Signaling By Receptor Tyrosine Kinases; from basic Principles to Cancer Therapy
We are interested in analyzing the mode of action of growth factor receptors and the
intracellular signaling pathways that activated in response to growth factor
stimulation. Receptor tyrosine kinases and cytoplasmic protein tyrosine kinases play
a critical role in the control of many cellular processes including: cell proliferation,
differentiation, metabolism, as well as cell survival and cell migration. Various
diseases are caused by dysfunctions in protein tyrosine kinases or in components of
signaling pathways that are activated by these enzymes. We have used biochemical
and genetic approaches as well as x-ray crystallography to determine the mechanism
of activation of receptor tyrosine kinases and the mode of action of downstream